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M94A2666.TXT
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1994-10-25
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Document 2666
DOCN M94A2666
TI HIV1/HIV2 EIA seronegativity in HIV1 subtype O infected patients in
France.
DT 9412
AU Ly TD; Lousset-Ajaka I; Chaix ML; Saragosti S; Brun-Vesinet F; Simon F;
Institut Alfred Fournier, Paris, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):252 (abstract no. PB0437). Unique
Identifier : AIDSLINE ICA10/94369909
AB OBJECTIVE: To study the serological reactivity of samples collected from
7 HIV1 subtype O infected patients PATIENTS-METHOD: 7 patients
(CDCII-III n = 3, CDC IV n = 4) originally from Cameroon were
hospitalised in Paris, France. HIV1 subtype O infection was diagnosed by
using PCR specific subtype O primers and serological reactivity on
specific Env subtype peptides. Sequential samples were tested on
different HIV1-2 EIA and rapid tests based on different antigens and
conjugate principles. RESULTS: Discordant results were observed
according to the antigen or to the conjugate used in the test. All the
samples were strongly reactive in EIA based on whole virus or
recombinant antigens with indirect conjugate fixation as shown in the
table. CONCLUSION: Screening test for HIV antibodies based on Env
peptides or the sandwich method could lack sensitivity in the case of
HIV1 subtype O infection. TABULAR DATA, SEE ABSTRACT VOLUME.
DE *AIDS Serodiagnosis Cameroon/ETHNOLOGY Comparative Study France
Human HIV Antibodies/*BLOOD HIV
Seropositivity/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY
HIV-1/CLASSIFICATION/*IMMUNOLOGY HIV-2/*IMMUNOLOGY *Immunoenzyme
Techniques Predictive Value of Tests Sensitivity and Specificity
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).